Longitudinal GWAS and genetic risk

Time-varying genetic effects on bone health across ancestries

Most genetic studies of bone use a single BMD measurement. This work models how genetic effects change over time.

Time-varying effect models for BMD trajectories
Multi-ancestry analysis across WHI, SOF, MrOS, and FHS
Identified SPTBN1 as a key regulator of BMD trajectories
Polygenic risk scores for major osteoporotic fracture

(Jung & Wu, 2026; Jung & Wu, 2024; Wu & Jung, 2023)

References

2026

SSRN

Genetic architecture of aging-related bone mineral density trajectories in diverse women implicates SPTBN1 in fracture risk

Jongyun Jung and Qing Wu

SSRN, 2026

Under review

DOI Bib HTML

@article{jung2026sptbn1,
  title = {Genetic architecture of aging-related bone mineral density trajectories in diverse women implicates {SPTBN1} in fracture risk},
  author = {Jung, Jongyun and Wu, Qing},
  journal = {SSRN},
  year = {2026},
  doi = {10.2139/ssrn.6031397},
  note = {Under review}
}

2024

PLOS One

Identification of bone mineral density associated genes with shared genetic architectures across multiple tissues: Functional insights for EPDR1, PKDCC, and SPTBN1

Jongyun Jung and Qing Wu

PLOS One, 2024

DOI Bib HTML

@article{jung2024sptbn1,
  title = {Identification of bone mineral density associated genes with shared genetic architectures across multiple tissues: Functional insights for {EPDR1}, {PKDCC}, and {SPTBN1}},
  author = {Jung, Jongyun and Wu, Qing},
  journal = {PLOS One},
  year = {2024},
  doi = {10.1371/journal.pone.0300535},
}

2023

J Transl Med

Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms

Qing Wu and Jongyun Jung

Journal of Translational Medicine, 2023

DOI Bib HTML

@article{wu2023prs,
  title = {Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms},
  author = {Wu, Qing and Jung, Jongyun},
  journal = {Journal of Translational Medicine},
  volume = {21},
  pages = {127},
  year = {2023},
  doi = {10.1186/s12967-023-03974-2},
}