Personalized fracture trajectories
HyTrax, a hybrid transformer model for longitudinal fracture risk
Standard tools such as FRAX estimate fracture risk from a single visit. HyTrax is a hybrid, trajectory-based model that uses the whole patient history instead.
- Transformer-based modeling of longitudinal health data
- Integrates repeated BMD, muscle metrics, clinical risk factors, and genetics
- Improves calibration and discrimination over FRAX, with external evaluation in the Framingham Heart Study
Presented at ASBMR 2025 (plenary poster), the ASBMR Muscle and Bone webinar (invited), ICFSR 2026 (late-breaking oral), and the 2026 Biomarkers of Aging Conference.